Brain-computer interfaces and human factors: the role of language and cultural differences-Still a missing gap?

Brain-computer interfaces (BCIs) aim at the non-invasive investigation of brain activity for supporting communication and interaction of the users with their environment by means of brain-machine assisted technologies. Despite technological progress and promising research aimed at understanding the influence of human factors on BCI effectiveness, some topics still remain unexplored. The aim of this article is to discuss why it is important to consider the language of the user, its embodied grounding in perception, action and emotions, and its interaction with cultural differences in information processing in future BCI research. Based on evidence from recent studies, it is proposed that detection of language abilities and language training are two main topics of enquiry of future BCI studies to extend communication among vulnerable and healthy BCI users from bench to bedside and real world applications. In addition, cultural differences shape perception, actions, cognition, language and emotions subjectively, behaviorally as well as neuronally. Therefore, BCI applications should consider cultural differences in information processing to develop culture- and language-sensitive BCI applications for different user groups and BCIs, and investigate the linguistic and cultural contexts in which the BCI will be used.

Linguistic and emotional responses evoked by pseudoword presentation: An EEG and behavioral study.

When the semantic properties of words are turned off, such as in pseudowords, the grammatical properties of the stimuli indicated through suffixes may provide cues to the meaning. The application of electroencephalography (EEG), combined with the pseudoword paradigm, allows for evaluating the effects of verbs and nouns as linguistic categories within the time course of processing. To contribute to the ongoing discussion regarding the functional processing of words from different grammatical classes, we conducted an EEG experiment, followed by a behavioral lexical decision task (LDT). The EEG and LDT indicated different neural and behavioral reactions to the presented grammar classes, allowing for a deeper understanding of the neuro- and psycholinguistic dimensions of grammar.

Oral health and mental health in healthy adults, a topic of primary prevention and health care, empirical results from two online studies.

Oral health is an important, yet often neglected aspect of health and well-being. Among geriatric populations, oral diseases, poor oral health, and reduced oral hygiene behavior are major comorbid factors of geriatric diseases such as dementia, cardiovascular diseases, or mental health conditions. However, little is known so far about the relationships between oral health and mental health in the younger adult population, who is yet not suffering from any disorder. In the present manuscript the results of two online studies, online study 1, n = 133, all-female sample and online study 2: n = 29, mixed gender sample, are reported that investigate the relationship between self-reported oral health impairments and preclinical symptoms of mental disorders including self-reported symptoms associated with depression or eating disorders as well as self-reported perceived stress and behavior change related to the COVID-19 pandemic. The results of both studies support links between self-reported oral health impairments, self-reported depressive symptoms (including anxiety and current affect) and symptoms related to eating disorders (such as bulimic behavior, body dissatisfaction or drive for thinness) among young adults and suggest that perceived stress may contribute to both, impaired oral health and impaired mental health in young adults (women and men). Supplementary Information: The online version contains supplementary material available at 10.1007/s12144-022-04121-8.

Analyzing and computing humans by means of the brain using Brain-Computer Interfaces - understanding the user - previous evidence, self-relevance and the user's self-concept as potential superordinate human factors of relevance.

Brain-computer interfaces (BCIs) are well-known instances of how technology can convert a user's brain activity taken from non-invasive electroencephalography (EEG) into computer commands for the purpose of computer-assisted communication and interaction. However, not all users are attaining the accuracy required to use a BCI consistently, despite advancements in technology. Accordingly, previous research suggests that human factors could be responsible for the variance in BCI performance among users. Therefore, the user's internal mental states and traits including motivation, affect or cognition, personality traits, or the user's satisfaction, beliefs or trust in the technology have been investigated. Going a step further, this manuscript aims to discuss which human factors could be potential superordinate factors that influence BCI performance, implicitly, explicitly as well as inter- and intraindividually. Based on the results of previous studies that used comparable protocols to examine the motivational, affective, cognitive state or personality traits of healthy and vulnerable EEG-BCI users within and across well-investigated BCIs (P300-BCIs or SMR-BCIs, respectively), it is proposed that the self-relevance of tasks and stimuli and the user's self-concept provide a huge potential for BCI applications. As potential key human factors self-relevance and the user's self-concept (self-referential knowledge and beliefs about one's self) guide information processing and modulate the user's motivation, attention, or feelings of ownership, agency, and autonomy. Changes in the self-relevance of tasks and stimuli as well as self-referential processing related to one's self (self-concept) trigger changes in neurophysiological activity in specific brain networks relevant to BCI. Accordingly, concrete examples will be provided to discuss how past and future research could incorporate self-relevance and the user's self-concept in the BCI setting - including paradigms, user instructions, and training sessions.

Enhancing Mental Health, Well-Being and Active Lifestyles of University Students by Means of Physical Activity and Exercise Research Programs.

Mental disorders (e.g., depression) and sedentary behavior are increasing, also among emerging adults. One particular target group of emerging adults with high sitting times and vulnerability to mental disorders are university students. In particular, anxiety and depressive symptoms as well as stress symptoms are very common among university students. The present manuscript discusses whether physical activity and exercise interventions can help to promote the mental health of emerging adults such as university students. The manuscript will summarize current scientific evidence and based on this evidence, introduce an university-based scientific research project that investigates if physical activity, exercise interventions and acute bouts of exercise of low- to moderate intensity can buffer perceived stress, alleviate mental health symptoms and strengthen well-being (psychologically and physiologically) among university students by positively influencing depressive and anxiety symptoms, perceived stress and emotion perception, body awareness and subjective well-being including overall quality of life. The research project, its concept, multimethod approach, and first results from available studies are discussed in relation to current scientific evidence, health care needs and future developments. The results from the studies conducted within the research project so far and that are briefly summarized in this manuscript suggest that physical activity, mental health and well-being are positively related, also in university students as an important group of emerging adults. The results further suggest that exercise interventions comprising aerobic exercises of low- to moderate intensity may work best to improve mental health (alleviate depressive symptoms and perceived stress) among university students after a few weeks of intervention. In addition, acute bouts of certain types of exercises (yoga in particular) seem to be particularly effective in changing perception of bodily signals, cardiac activity and emotion processing immediately after the exercise. The results underscore the importance of systematic investigations of the combined examination of psychological and physiological factors that promote an active lifestyle and that strengthen mental health and well-being (psychologically and physiologically) among emerging adults such as university students.

Self-related primes reduce congruency effects in the Stroop task.

Theoretical accounts of self-representation assume a privileged role for information that is linked to the self and suggest that self-relevant stimuli capture attention in a seemingly obligatory manner. However, attention is not only biased toward self-relevant information, but self-relevant information might also tune attention more broadly, for instance, by engaging cognitive control processes that regulate allocation of attention. Indeed, research in social, clinical, and developmental sciences predicts a close link between a cognitive representation of the self and cognitive control processes. The present research is concerned with such a possible signaling function of the self to recruit cognitive control and tested predictions that follow from this view using the well-known Stroop task. Participants identified the print color of words. Self-reference was manipulated such that a prime was presented before or together with a Stroop word that comprised of either a possessive pronoun (e.g., "my green") or a definite/indefinite article as control (e.g., "the/a green"). Results of three experiments (Ntotal = 137) showed that self-reference priming reduced the congruency effect in the Stroop task relative to control conditions. This finding is incompatible with an attentional bias account assuming that self-relevant distractors always impair performance, but rather suggests that stimuli relevant to the self can facilitate cognitive control processes. (PsycInfo Database Record (c) 2022 APA, all rights reserved).

The verb-self link: An implicit association test study.

Agency is defined as the ability to assign and pursue goals. Given people's focus on achieving their own goals, agency has been found to be strongly linked to the self. In two studies (N = 168), we examined whether this self-agency link is visible from a linguistic perspective. As the preferred grammatical category to convey agency is verbs, we hypothesize that, in the Implicit Association Test (IAT), verbs (vs. nouns) would be associated more strongly with the self (vs. others). Our results confirmed this hypothesis. Participants exhibited particularly fast responses when reading self-related stimuli (e.g., "me" or "my") and verb stimuli (e.g., "deflect" or "contemplate") both necessitated pressing an identical rather than different response keys in the IAT (d = .25). The finding connects two streams of literature-on the link between agency and verbs and on the link between self and agency-suggesting a triad between self, agency, and verbs. We argue that this verb-self link (1) opens up new perspectives for understanding linguistic expressions of agency and (2) expands our understanding of how word choice impacts socio-cognitive processing.

Can Yoga Boost Access to the Bodily and Emotional Self? Changes in Heart Rate Variability and in Affective Evaluation Before, During and After a Single Session of Yoga Exercise With and Without Instructions of Controlled Breathing and Mindful Body Awareness in Young Healthy Women.

Exercise is indispensable for a healthy lifestyle. Yoga exercise can have positive effects on well-being and on cardiac autonomic activity making it an ideal intervention for improving mind-body interactions and resilience to physical and mental stressors. Emotions trigger especially strong bodily and affective-cognitive responses because of their social relevance for the self and their biological relevance of mobilizing the organism for action. This study investigates whether changes in emotion processing related to self-other referential processing and changes in cardiac autonomic activity, reflected by heart rate variability (HRV), occur immediately after already a single session of yoga exercise when yoga postures are practiced with or without breathing- and mindful body awareness instructions. Women, all university students (N = 34, final sample: n = 30, n = 25 naïve to yoga practice) were randomly assigned to two experimental groups who performed the same yoga exercises with or without controlled breathing and mindfulness instructions. Emotional, self-other referential processing, awareness of bodily signals and HRV indicators were investigated before and after the exercise using standardized experimental tasks, standardized questionnaires, and mobile recording devices. Exercising for 30 minutes changed cardiac activity significantly. HRV measures showed adaptability of cardiac activity during the exercise as well as during the affective task post- to pre-exercise. Exercising with breathing instructions and mindful body awareness had no superior effects on cardiac, particularly parasympathetic activity, compared to practicing the same movements without such explicit instructions. Self-referential processing did not change; however, participants were faster and more accurate in their affective judgments of emotional stimuli [regardless of their reference (self/other)], and showed better awareness of bodily signals after compared to before the exercise session. The results support immediate, adaptive effects of yoga exercise on cardiac and affective-cognitive processing in an all-female healthy sample. Therefore, yoga exercise could be recommended as a physical activity for boosting cardiac and emotional resilience in this target group.

A Short, Multimodal Activity Break Incorporated Into the Learning Context During the Covid-19 Pandemic: Effects of Physical Activity and Positive Expressive Writing on University Students' Mental Health-Results and Recommendations From a Pilot Study.

Physical inactivity, sedentary behavior and mental ill health, due to high levels of perceived stress or self-reported depressive symptoms, are highly prevalent among university students. There are concerns that these behaviors and mental symptoms have significantly increased during the current Covid-19 pandemic, partly because academic life has changed considerably from face-to-face communication to e-learning and studying at home. Self-regulation and physical activity are hard to maintain during pandemic lockdowns. Short activity breaks could be helpful to avoid physical inactivity and sustain mental health. The breaks should comprise short and easy-implementable physical activity exercises that can be integrated into the learning context. Moreover, cognitive interventions, such as writing about positive events and feelings might help as coping strategy for self-regulation during study breaks. This study investigated and compared the effects of a physical activity intervention and a cognitive intervention (positive expressive writing) on mental health among university students. Both interventions are particularly suitable for use at home. N = 20 university students, studying in Germany, were assigned to a physical activity group or a cognitive intervention group. The physical activity intervention consisted of a mix of physical exercises including endurance exercises, muscular strength, relaxation, and ballroom dance movements. The interventions were carried out guided, once a week, for 5-10 mins at the beginning of classes. The effects of group × time showed no significant interaction on self-reported perceived stress, mood, quality of life (QoL) assessed online and compared at the beginning of the term before the intervention (T0) and at the end of the term after the intervention (T3). However, the physical activity group reported a similar physical activity level per day over time, while the cognitive intervention group showed a decrease in physical activity from T0 to T3. Low-dose, short physical activity interventions as well as cognitive interventions consisting of positive expressive writing could buffer university students' perceived stress, mood, and QoL across the term. Moreover, both interventions seem to be promising in buffering the negative side effects of stress during the Covid-19 pandemic.

An Ontology-Based Framework for Psychological Monitoring in Education During the COVID-19 Pandemic.

BACKGROUND: Especially in the current crisis of the COVID-19 pandemic and the lockdown it entailed, technology became crucial. Machines need to be able to interpret and represent human behavior, to improve human interaction with technology. This holds for all domains but even more so for the domain of student behavior in relation to education and psychological well-being. METHODS: This work presents the theoretical framework of a psychologically driven computing ontology, CCOnto, describing situation-based human behavior in relation to psychological states and traits. In this manuscript, we use and apply CCOnto as a theoretical and formal description system to categorize psychological factors that influence student behavior during the COVID-19 situation. By doing so, we show the added value of ontologies, i.e., their ability to automatically organize information from unstructured human data by identifying and categorizing relevant psychological concepts. RESULTS: The already existing CCOnto was modified to automatically categorize university students' state and trait markers related to different aspects of student behavior, including learning, worrying, health, and socially based on psychological theorizing and psychological data conceptualization. DISCUSSION: The paper discusses the potential advantages of using ontologies for describing and modeling psychological research questions. The handling of dataset completion, unification, and its explanation by means of Artificial Intelligence and Machine Learning models is also discussed.

The Human Self Has Two Serial Aspects and Is Dynamic: A Concept Based on Neurophysiological Evidence Supporting a Multiple Aspects Self Theory (MAST).

The self is an increasingly central topic in current neuroscience. Understanding the neural processes that are involved in self-referential processing and functioning may also be crucial to understanding consciousness. The current short communication goes beyond the typical concept that the self is singular, as has been assumed from neuroanatomical descriptions of the self by fMRI and PET studies. Long ago, theoretically, the idea of multiple aspects of the human self-arose, highlighting a dynamic organizational structure, but an increasing number of electrophysiological brain imaging studies, searching for the temporal dynamics of self-referential brain processes, now has empirical evidence supporting their existence. This short communication focuses on the theoretical idea of a dynamic self and provides first preliminary empirical evidence, including results from own studies of the authors, in support of, and highlights the serial dynamics of the human self, suggesting a primitive Me1 and an elaborate Me2 (a non-personal and a personal self). By focusing on the temporal dimension of the self, we propose that multiple aspects of the self can be distinguished based on their temporal sequence. A multiple aspects Self Theory (MAST) is proposed. This model is meant as a theoretical framework for future studies providing further support.

Does Attentional Focus Influence Psychophysiological Responses to an Acute Bout of Exercise? Evidence From an Experimental Study Using a Repeated-Measures Design.

Attentional focus during aerobic exercise has been studied in the context of sports performance, injury prevention and affective experience. Previous research suggests that an additional mental task parallel to the physical activity might influence exercise experience and performance. It has been tested if attentional focus influences cardiovascular activity, positive/negative affect, and subjective exertion during a cycling exercise. Data from N = 30 female participants has been collected using a repeated measures design, with the following experimental manipulations: (A) an internal attention focus (i.e., paying attention to force production of the quadriceps muscles), (B) an external attention focus (i.e., paying attention to changes in brightness in the cycling track simulation), and as control conditions, (C) exercise without attention focus (i.e., no specific instruction was given) and (D) no exercise, no attention focus. Subjective affect and subjective exertion were assessed, and changes in cardiovascular activity were recorded via mobile impedance cardiography (ICG) at rest, during and after the exercise, including HR, HRV (RMSSD, HF), PEP, CO, SV, LVET, and RSA. Exercise was associated with adaptations in cardiovascular activity, positive/negative affect, and subjective exertion. However, this did not interact with attentional focus. The original hypothesis could not be supported: instructed attentional focus does not influence affect, exertion, or cardiovascular activity during a cycling exercise. Therefore, attentional focusing during exercise does not appear to put notable additional mental demands on the physically active participant. Nonetheless, impedance cardiography delivered reliable measurements even during the cycling exercise.

How do you feel during the COVID-19 pandemic? A survey using psychological and linguistic self-report measures, and machine learning to investigate mental health, subjective experience, personality, and behaviour during the COVID-19 pandemic among university students.

BACKGROUND: The WHO has raised concerns about the psychological consequences of the current COVID-19 pandemic, negatively affecting health across societies, cultures and age-groups. METHODS: This online survey study investigated mental health, subjective experience, and behaviour (health, learning/teaching) among university students studying in Egypt or Germany shortly after the first pandemic lockdown in May 2020. Psychological assessment included stable personality traits, self-concept and state-like psychological variables related to (a) mental health (depression, anxiety), (b) pandemic threat perception (feelings during the pandemic, perceived difficulties in describing, identifying, expressing emotions), (c) health (e.g., worries about health, bodily symptoms) and behaviour including perceived difficulties in learning. Assessment methods comprised self-report questions, standardized psychological scales, psychological questionnaires, and linguistic self-report measures. Data analysis comprised descriptive analysis of mental health, linguistic analysis of self-concept, personality and feelings, as well as correlational analysis and machine learning. N = 220 (107 women, 112 men, 1 = other) studying in Egypt or Germany provided answers to all psychological questionnaires and survey items. RESULTS: Mean state and trait anxiety scores were significantly above the cut off scores that distinguish between high versus low anxious subjects. Depressive symptoms were reported by 51.82% of the student sample, the mean score was significantly above the screening cut off score for risk of depression. Worries about health (mental and physical health) and perceived difficulties in identifying feelings, and difficulties in learning behaviour relative to before the pandemic were also significant. No negative self-concept was found in the linguistic descriptions of the participants, whereas linguistic descriptions of feelings during the pandemic revealed a negativity bias in emotion perception. Machine learning (exploratory) predicted personality from the self-report data suggesting relations between personality and subjective experience that were not captured by descriptive or correlative data analytics alone. CONCLUSION: Despite small sample sizes, this multimethod survey provides important insight into mental health of university students studying in Egypt or Germany and how they perceived the first COVID-19 pandemic lockdown in May 2020. The results should be continued with larger samples to help develop psychological interventions that support university students across countries and cultures to stay psychologically resilient during the pandemic.

Emoji as Affective Symbols: Affective Judgments of Emoji, Emoticons, and Human Faces Varying in Emotional Content.

An important function of emoji as communicative symbols is to convey emotional content from sender to receiver in computer-mediated communication, e. g., WhatsApp. However, compared with real faces, pictures or words, many emoji are ambiguous because they do not symbolize a discrete emotion or feeling state. Thus, their meaning relies on the context of the message in which they are embedded. Previous studies investigated affective judgments of pictures, faces, and words suggesting that these stimuli show a typical distribution along the big two emotion dimensions of valence and arousal. Also, emoji and emoticons have been investigated recently for their affective significance. The present study extends previous research by investigating affective ratings of emoji, emoticons and human faces and by direct comparison between them. In total, 60 stimuli have been rated by 83 participants (eight males, age: 18-49 years), using the non-verbal Self-Assessment Manikin Scales for valence and arousal. The emotionality of the stimuli was measured on a 9-point Likert scale. The results show significant main effects of the factors "stimulus category" and "discrete emotion" including emotionality, valence and arousal. Also, the interaction between these two main factors was significant. Emoji elicited highest arousal, whereas stimuli related to happiness were rated highest in valence across stimulus categories. Angry emoji were rated highest in emotionality. Also, the discrete emotion was best recognized in emoji, followed by human face stimuli and lastly emoticons.

Yoga, Dance, Team Sports, or Individual Sports: Does the Type of Exercise Matter? An Online Study Investigating the Relationships Between Different Types of Exercise, Body Image, and Well-Being in Regular Exercise Practitioners.

Physical activity, specifically exercising, has been suggested to improve body image, mental health, and well-being. With respect to body image, previous findings highlight a general benefit of exercise. This study investigates whether the relationship between exercising and body image varies with the type of exercise that individuals preferentially and regularly engage in. In addition, physical efficacy was explored as a potential psychological mediator between type of exercise and body image. Using a cross-sectional design, healthy regular exercise practitioners of yoga, ballroom dance, team sports, or individual sports as well as healthy adults reporting no regular exercising were surveyed. Body image and its different facets were assessed by a set of standardized self-report questionnaires, covering perceptual, cognitive, and affective body image dimensions particularly related to negative body image. In addition, participants were questioned with regard to mental health. Participants were 270 healthy adults. Descriptive statistics, measures of variance (ANOVA), and multiple linear regression analysis with orthogonal contrasts were performed to investigate differences between the different exercise and non-exercise groups in the variables of interest. In line with the hypotheses and previous findings, the statistic comparisons revealed that body dissatisfaction (as one important factor of negative body image) was most pronounced in the non-exercise group compared to all exercise groups [contrast: no exercise versus exercise (all groups taken together)]. Physical efficacy, as assessed with a standardized questionnaire, mediated the difference between type of exercise (using contrasts) and body image including perceptual, cognitive, and affective body image dimensions. The findings shed light on so far less systematically investigated questions regarding the relationship between types of exercise, like yoga and ballroom dance, and body image. The results underscore the relevance of considering possible influencing factors in exercise research, such as the perception of one's physical efficacy as a mediator of this relationship.

Are You Willing to Self-Disclose for Science? Effects of Privacy Awareness and Trust in Privacy on Self-Disclosure of Personal and Health Data in Online Scientific Studies-An Experimental Study.

Digital interactions via the internet have become the norm rather than the exception in our global society. Concerns have been raised about human-centered privacy and the often unreflected self-disclosure behavior of internet users. This study on human-centered privacy follows two major aims: first, investigate the willingness of university students (as digital natives) to disclose private data and information about their person, social and academic life, their mental health as well as their health behavior habits, when taking part as a volunteer in a scientific online survey. Second, examine to what extent the participants' self-disclosure behavior can be modulated by experimental induction of privacy awareness (PA) or trust in privacy (TIP) or a combination of both (PA and TIP). In addition, the role of human factors such as personality traits, gender or mental health (e.g., self-reported depressive symptoms) on self-disclosure behavior was explored. Participants were randomly assigned to four experimental groups. In group A (n = 50, 7 males), privacy awareness (PA) was induced implicitly by the inclusion of privacy concern items. In group B (n = 43, 6 males), trust in privacy (TIP) was experimentally induced by buzzwords and by visual TIP primes promising safe data storage. Group C (n = 79, 12 males) received both, PA and TIP induction, while group D (n = 55, 9 males) served as control group. Participants had the choice to answer the survey items by agreeing to one of a number of possible answers including the options to refrain from self-disclosure by choosing the response options "don't know" or "no answer." Self-disclosure among participants was high irrespective of experimental group and irrespective of psychological domains of the information provided. The results of this study suggest that willingness of volunteers to self-disclose private data in a scientific online study cannot simply be overruled or changed by any of the chosen experimental privacy manipulations. The present results extend the previous literature on human-centered privacy and despite limitations can give important insights into self-disclosure behavior of young people and the privacy paradox.

Regular Physical Activity, Short-Term Exercise, Mental Health, and Well-Being Among University Students: The Results of an Online and a Laboratory Study.

The health benefits of regular physical activity and aerobic exercise are undisputed in the literature. The present series of pilot studies had two major objectives: (a) examine mental health, well-being, and regular physical activity of university students and (b) explore the potential health benefits of short-term aerobic exercise on university students in an online and a laboratory study. Mental health and well-being were measured before (Time 1, T1) and after (Time 2, T2) a 6 week (online study) and 2 week (laboratory study) low- to moderate-intensity aerobic exercise intervention. Mental health and well-being were assessed using standardized self-report measures of depression, anxiety, positive and negative affect, perceived stress and coping strategies, body dissatisfaction, and quality of life. The effects of the aerobic exercise were compared to a cognitive non-exercise control condition (online study), motor coordination exercise (laboratory study), and a waiting list (online and laboratory). A total of 185 university students were recruited from German universities at T1. Further, 74 (women: n = 67) students completed the 6-week intervention. Similarly, 32 (women: n = 30) participants completed the 2 week intervention (laboratory study). At T1, 36.6% of the students (women and men) reported experiencing depressive symptoms. 41.83% of them (women and men) had high levels of state anxiety. All the students reported experiencing stress (e.g., due to uncertainty related to factors such as their finances, job, and social relationships). At T1, regular physical activity was negatively correlated with self-reported depression, anxiety, and perceived psychosomatic stress and positively correlated with quality of life and positive affect. Among women, cardiovascular fitness (operationalized as resting heart rate variability) was negatively correlated with self-reported anxiety (state) and depression at T1 (laboratory study). The 6 week aerobic exercise intervention resulted in significant improvements in self-reported depression, overall perceived stress, and perceived stress due to uncertainty. The present results confirm that there is a relationship between regular physical activity, cardiovascular fitness, mental health, and well-being among university students. They support the hypothesis that short-term aerobic exercise interventions can act as buffer against depression and perceived stress in university students after 6 weeks of aerobic exercise of low to moderate intensity.

Anticipatory feelings: Neural correlates and linguistic markers.

This review introduces anticipatory feelings (AF) as a new construct related to the process of anticipation and prediction of future events. AF, defined as the state of awareness of physiological and neurocognitive changes that occur within an oganism in the form of a process of adapting to future events, are an important component of anticipation and expectancy. They encompass bodily-related interoceptive and affective components and are influenced by intrapersonal and dispositional factors, such as optimism, hope, pessimism, or worry. In the present review, we consider evidence from animal and human research, including neuroimaging studies, to characterize the brain structures and brain networks involved in AF. The majority of studies reviewed revealed three brain regions involved in future oriented feelings: 1) the insula; 2) the ventromedial prefrontal cortex (vmPFC); and 3) the amygdala. Moreover, these brain regions were confirmed by a meta-analysis, using a platform for large-scale, automated synthesis of fMRI data. Finally, by adopting a neurolinguistic and a big data approach, we illustrate how AF are expressed in language.

Affective Language, Interpretation Bias and Its Molecular Genetic Variations: Exploring the Relationship Between Genetic Variations of the OXTR Gene (rs53576 and rs2268498) and the Emotional Evaluation of Words Related to the Self or the Other.

Several studies have demonstrated links between oxytocin and socio-emotional information processing. Regarding the frequently studied single nucleotide polymorphism (SNP) rs53576 and the less studied, functional polymorphism rs2268498 of the oxytocin receptor (OXTR) gene, previous research suggested that their variants might be associated with different proficiency in the processing of social information. Differences between the genotype variants are not restricted to non-verbal stimulus processing but have also been reported in the verbal domain. Moreover, there is evidence that oxytocin expression influences empathic communication and language development during childhood, indicating that language-based theory-of-mind abilities may be affected by interindividual differences in OXTR genotypes as well. The present study therefore investigates whether two prominent SNPs of the OXTR gene (rs53576 GG vs. A+; rs2268498 TT vs. C+) also play a role in the affective evaluation of verbal stimuli varying in emotional valence and in self-other reference. Participants (N = 149 Caucasian participants, 104 females; A+: n = 80, GG: n = 69; C+: n = 98, TT: n = 51) were presented a series of written, self-, other-, and unreferenced words of positive, negative, and neutral valence and asked to affectively evaluate each word pair as positive, negative, or neutral by button press. In line with previous research, reaction times and accuracy (number of valence-congruent responses) showed a self-positivity bias (i.e., preferential processing of self-related positive words), which, however, was unaffected by participants' genotype. Regarding affective evaluation of neutral words (interpretation bias), A+ carriers displayed a weaker positive interpretation bias compared to GG carriers in the other- and unreferenced stimulus categories. C+ carriers showed a weaker positive interpretation bias than TT carriers in the self-reference condition and in the other-reference condition. These effects were independent from participants' gender. The present results suggest that the OXTR genotype and hence participants' genetic oxytocin sensitivity may cause an interpretation bias in the spontaneous appraisal of neutral words.

Whose emotion is it? Measuring self-other discrimination in romantic relationships during an emotional evaluation paradigm.

In healthy subjects, emotional stimuli, positive stimuli in particular, are processed in a facilitated manner as are stimuli related to the self. These preferential processing biases also seem to hold true for self-related positive stimuli when compared to self-related negative or other-related positive stimuli suggesting a self-positivity bias in affective processing. The present study investigates the stability of this self-positivity bias and its possible extension to the emotional other in a sample of N = 147 participants including single participants (n = 61) and individuals currently in a romantic relationship (n = 86) reporting moderate to high levels of passionate love. Participants were presented a series of emotional and neutral words that could be related to the reader's self (e.g., "my pleasure", "my fear"), or to an insignificant third person, unknown to the reader (e.g., "his pleasure", "his fear") or devoid of any person reference (e.g., "the pleasure", "the fear"). The task was to read the words silently and to evaluate the word pairs in reference to one's own feelings elicited during reading. Results showed a self-positivity bias in emotional judgments in all participants, particularly in men. Moreover, participants in a romantic relationship (women and men) evaluated positive, other-related stimuli more often as valence-congruent with one's own feelings than single participants. Taken together, these findings support the idea of a self-positivity bias in healthy subjects and an expansion of this bias while being in a romantic relationship.